Modalert 200 Tablet is a powerful drug that can help to keep you awake. It works by increasing your brain’s levels of dopamine and also increases levels of two other wake-promoting chemicals.
It’s a core therapy for most people with narcolepsy and other sleep disorders like obstructive sleep apnea and shift work sleep disorder. However, finding the best dose and minimizing side effects can take time.
Modafinil
Modafinil, or Provigil, is one of the most popular “smart drugs” – the seductive group of pharmaceutical friends that promise enhanced memory, motivation, and an ability to focus for hours. These smart drugs are widely available as over-the-counter medications and are popular among college students, working professionals, and individuals seeking to overcome chronic fatigue or depression.
First approved by the FDA to treat narcolepsy in 1998, modafinil can be used to reduce excessive sleepiness in patients with obstructive sleep apnea, shift work sleep disorder, and other conditions. Studies show that modafinil significantly improves objectively measured sleep latency and waking activity (MSLT and MWT) and subjectively assessed sleepiness level (ESS) compared to placebo. It also increases health-related quality of life (SF-36) score and fewer constraints on daily activities due to health problems, including pain, fatigue, or poor mental health.
It is believed that modafinil promotes wakefulness by increasing levels of the natural substance acetylcholine in areas of the brain associated with wakefulness. Modafinil Online Australia has been reported to have mood-brightening and memory-enhancing effects, and some studies suggest that it may increase epinephrine and norepinephrine in the brain. It is not known how modafinil affects other neurochemical systems involved in regulating sleep and wakefulness, however.
Armodafinil
Armodafinil works similarly to modafinil but has longer half-lives. It may also be more effective for people with certain sleep disorders. Both are a part of a group of medications called wakefulness-promoting agents.
This medication comes as an oral tablet and is usually taken once a day. It is often prescribed to treat narcolepsy, obstructive sleep apnea, or shift work sleep disorder. It can also help reduce fatigue caused by obstructive sleep apnea or narcolepsy. It is usually used in combination with other treatments such as breathing devices or surgery for sleep apnea and hypersomnia.
Studies show that this drug improves sleepiness in people with these conditions and makes it easier to stay awake during the day. It can also help improve cognitive function and mood in those with these conditions. It can help people with fatigue caused by long work hours, night shifts, or unpredictable schedules.
This medication is a controlled substance and may cause physical or psychological dependence. Take it only as directed by your doctor. Do not increase your dose or take it more often than prescribed. It is not a substitute for getting enough sleep. Keep this medication in a secure place where others cannot get it and do not share it with anyone else. This medication can interact with other drugs, including prescription and over-the-counter medicines, vitamins, and herbal products.
Oxybates
Sodium oxybate is the sodium salt form of gamma-hydroxybutyrate (GHB). It is a highly effective medication for reducing daytime sleepiness and cataplexy in people with narcolepsy. GHB is a naturally occurring compound within the central nervous system that acts as a natural depressant. It is also being studied for the treatment of Fibromyalgia Syndrome (FMS). A randomized placebo-controlled trial of Sodium Oxybate showed significant improvements in pain, sleep, and other symptoms associated with FMS.
In a study of patients with severe narcolepsy and cataplexy who were refractory to other treatments, oxybates significantly reduced the Epworth Sleepiness Score (ESS) and improved cataplexy in 65% of patients. The most common optimal dose was 9 g/night. Sodium oxybate is taken at night before bedtime and should be swallowed whole with a full glass of water. It works by binding to receptors for the inhibitory neurotransmitter GABA and decreasing its activity, thereby improving alertness.
It can take several weeks for oxybates to reach an optimum effect and begin to improve cataplexy. Most doctors start patients on a low to moderate dose and gradually increase it over a few weeks if needed. Sodium oxybate can cause high blood pressure and serious heart problems if it is taken for too long or in large amounts. It should not be used by people with high blood pressure, kidney or liver problems, or who are taking other medications that may cause drowsiness.
Amphetamines
Amphetamines (benzedrine, dexedrine, dextroamphetamine) and closely related medications are central nervous system stimulants that increase the body’s levels of dopamine, which is an important wake-promoting neurotransmitter. They also increase levels of serotonin and noradrenaline to a lesser degree. These drugs improve alertness for three to four hours and suppress appetite, but they can cause jitteriness, headache, anxiety, heart palpitations, and nausea.
They are prescribed by doctors to treat attention deficit hyperactivity disorder and narcolepsy. They are commonly misused and abused as illicit drugs, especially speed (also known as ‘crystal meth’).
In pill form, amphetamines can be swallowed orally or crushed into a powder and sniffed or injected. They come in short-acting forms that improve alertness for a few hours, and long-acting forms that last six to eight hours. Many people with narcolepsy find it most useful to take a long-acting pill in the morning and a short-acting one before their most sleepy times of the day.
Misuse and abuse of amphetamines can lead to addiction. A person may develop a tolerance to the drug, meaning they need to take larger doses to feel its effects. They may also experience negative consequences at work or school — health, financial, legal, or relationship problems — as a result of their use of amphetamines. If you think someone has overdosed on amphetamines, call triple zero (000) for an ambulance immediately. Read More Blog…
